Cardiovascular diseases

Julius Clinical has a lengthy track record in cardiovascular diseases, due in no small part to the academic expertise of Chief Scientific Officer Prof. Rick Grobbee in this field of medicine.

Thought Leaders

Dr. Marco Alings

Associated Scientist

Marco Alings, MD, PhD, FESC, is a practicing cardiologist/electrophysiologist and Director of the cardiology training program at the Amphia Ziekenhuis, Breda, the Netherlands. After obtaining his PhD in the field of cellular electrophysiology, Dr. Alings earned a medical degree at the University of Amsterdam. 

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Prof. John Kastelein

Consulting Scientist

John J.P. Kastelein (1954) is Professor of Medicine at the Department of Vascular Medicine at the Academic Medical Center (AMC) of the University of Amsterdam, where he holds the Strategic Chair of Genetics of Cardiovascular Disease.

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Total patients

35026

Total sites

1534

Publications

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Effect of aleglitazar on cardiovascular outcomes after acute coronary syndrome in patients with type 2 diabetes mellitus: the AleCardio randomized clinical trial.

Lincoff AM, Tardif JC, Schwartz GG, Nicholls SJ, Rydén L, Neal B, Malmberg K, Wedel H, Buse JB, Henry RR, Weichert A, Cannata R, Svensson A, Volz D, Grobbee DE; AleCardio Investigators.

JAMA. 2014 Apr 16;311(15):1515-25. doi: 10.1001/jama.2014.3321. PubMed PMID: 24682069

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Evaluation of the dual peroxisome proliferator-activated receptor α/γ agonist aleglitazar to reduce cardiovascular events in patients with acute coronary syndrome and type 2 diabetes mellitus: rationale and design of the AleCardio trial.

Evaluation of the dual peroxisome proliferator-activated receptor α/γ agonist aleglitazar to reduce cardiovascular events in patients with acute coronary syndrome and type 2 diabetes mellitus: rationale and design of the AleCardio trial.

Lincoff AM, Tardif JC, Neal B, Nicholls SJ, Rydén L, Schwartz GG, Malmberg K, Buse JB, Henry RR, Wedel H, Weichert A, Cannata R, Grobbee DE.

Am Heart J. 2013 Sep;166(3):429-34. doi: 10.1016/j.ahj.2013.05.013. Epub 2013 Jul 26. PubMed PMID: 24016490

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Follow-up of Blood-Pressure Lowering and Glucose Control in Type 2 Diabetes

Sophia Zoungas, M.D., Ph.D., John Chalmers, M.D., Ph.D., Bruce Neal, M.D., Ph.D., Laurent Billot, M.Sc., Qiang Li, M.Biostat., Yoichiro Hirakawa, M.D., Ph.D., Hisatomi Arima, M.D., Ph.D., Helen Monaghan, B.Sc., Rohina Joshi, M.D., Ph.D., Stephen Colagiuri, M.D., Ph.D., Mark E. Cooper, M.D., Ph.D., Paul Glasziou, M.D., Ph.D., Diederick Grobbee, M.D., Ph.D., Pavel Hamet, M.D., Ph.D., Stephen Harrap, M.D., Ph.D., Simon Heller, M.D., Liu Lisheng, M.D., Giuseppe Mancia, M.D., Michel Marre, M.D., Ph.D., David R. Matthews, B.M., Ph.D., Carl E. Mogensen, M.D., Ph.D., Vlado Perkovic, M.D., Ph.D., Neil Poulter, M.D., F.Med.Sci., Anthony Rodgers, M.D., Ph.D., Bryan Williams, M.D., Ph.D., Stephen MacMahon, D.Sc., Ph.D., Anushka Patel, M.D., Ph.D., and Mark Woodward, Ph.D. for the ADVANCE-ON Collaborative Group.

N Engl J Med. 2014 Oct 9;371(15):1392-406. doi: 10.1056/NEJMoa1407963.

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Intensive blood glucose control and vascular outcomes in patients with Type 2 Diabetes

ADVANCE Collaborative Group, Patel A, MacMahon S, Chalmers J, Neal B, Billot L, Woodward M, Marre M, Cooper M, Glasziou P, Grobbee D, Hamet P, Harrap S, Heller S, Liu L, Mancia G, Mogensen CE, Pan C, Poulter N, Rodgers A, Williams B, Bompoint S, de Galan BE, Joshi R, Travert F. 

N Engl J Med. 2008 Jun 12;358(24):2560-72. Epub 2008 Jun 6. PubMed PMID: 18539916.

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Severe Hypoglycemia and Risks of Vascular Events and Death

Zoungas S, Patel A, Chalmers J, de Galan BE, Li Q, Billot L, Woodward M, Ninomiya T, Neal B, MacMahon S, Grobbee DE, Kengne AP, Marre M, Heller S; ADVANCE Collaborative Group.

N Engl J Med. 2010 Oct 7;363(15):1410-8. PubMed PMID: 20925543.

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Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial

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