Metabolic diseases

As with cardiovascular diseases, Julius Clinical has a strong track record of expertise and performance in the closely related field of metabolic diseases, including large trials involving patients with obesity and diabetes mellitus. Our experience with trials in metabolic diseased have all contributed to advances in the treatment of these conditions.

Thought Leaders

Prof. Dick de Zeeuw

Associated Scientist

Dick de Zeeuw is Professor and Chair of the Department of Clinical Pharmacology at the University of Groningen, the Netherlands, with a joint appointment in the Department of Nephrology.

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Prof. Joost Hoekstra

Associated Scientist

Prof. dr. Joost Hoekstra's scientific expertise is focused on clinical diabetology. In this broad area he supported some 20 PhD students and gave numerous lectures, primarily within the Netherlands. He was co-author of some 200 scientific publications, the majority of which dealt with diabetes subjects.  

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Total patients

9470

Total sites

251

Publications

Impact of hypoglycaemia on patient-reported outcomes from a global, 24-country study of 27,585 people with type 1 and insulin-treated type 2 diabetes

Kamlesh, Kamlesh et al., “Impact of hypoglycaemia on patient-reported outcomes from a global, 24-country study of 27,585 people with type 1 and insulin-treated type 2 diabetes”. Diabetes Research and Clinical Practice 130 (2017) 121–129. 

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Rates and predictors of hypoglycaemia in 27 585 people from 24 countries with insulin‐treated type 1 and type 2 diabetes: the global HAT study.

Khunti, Kamlesh, et al. "Rates and predictors of hypoglycaemia in 27 585 people from 24 countries with insulin‐treated type 1 and type 2 diabetes: the global HAT study." Diabetes, Obesity and Metabolism 18.9 (2016): 907-915.

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Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE): rationale and study design

Hans-Henrik Parving, Barry M. Brenner, John. J. V. McMurray, Dick de Zeeuw, Steven M. Haffner, Scott D. Solomon, Nish Chaturvedi, Mathieu Ghadanfar, Nicole Weissbach, Zhihua Xiang, Juergen Armbrecht and Marc A. Pfeffer.

Nephrol Dial Transplant (2009) 24: 1663–1671

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Cardiorenal End Points in a Trial of Aliskiren for Type 2 Diabetes

Hans-Henrik Parving,Barry M. Brenner, John J.V. McMurray, Dick de Zeeuw, Steven M. Haffner, Scott D. Solomon, Nish Chaturvedi, Frederik Persson, Akshay S. Desai, Maria Nicolaides, Alexia Richard, Zhihua Xiang, Patrick Brunel Marc A. Pfeffer, for the ALTITUDE Investigators

N Engl J Med 2012;367:2204-13.

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A prediction of the renal and cardiovascular efficacy of aliskiren in ALTITUDE using short-term changes

PA Smink, J Hoekman, DE Grobbee, MJC Eijkemans, H-H Parving, F Persson, H Ibsen, L Lindholm, K Wachtell, D de Zeeuw and HJ Lambers Heerspink.

European Journal of Preventive Cardiology 2014 21: 434 

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